Journal
NATURE NEUROSCIENCE
Volume 14, Issue 11, Pages 1407-1409Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2935
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Funding
- US National Institutes of Health [5T32GM008111, 5R01NS064025, 2P30NS047466]
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Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.
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