Journal
NATURE NEUROSCIENCE
Volume 13, Issue 7, Pages 819-821Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2563
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Funding
- US National Institutes of Health [NS61479, DC008449, DC01919]
- FRAXA Research Foundation
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In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.
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