Journal
NATURE NEUROSCIENCE
Volume 13, Issue 4, Pages 411-413Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2511
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Funding
- Deutsche Forschungsgemeinschaft [SFB 596, A13]
- German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung) [01GZ0713, 13N9268]
- German Federal Ministry of Economics and Technology (Bundesministerium fur Wirtschaft und Technologie) [16IN0675]
- European Union [GSK3, FP-7-223276]
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Microglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease by phagocytosing amyloid-beta. Two-photon in vivo imaging of neuron loss in the intact brain of living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination, indicated by locally increased number and migration velocity of microglia around lost neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-microglia communication, prevented neuron loss.
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