Journal
NATURE NEUROSCIENCE
Volume 13, Issue 11, Pages 1338-1344Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2672
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Funding
- National Institutes of Health [NS048271, HD069184, MH088485, MH090258, AG024984, NS047344, MH087874]
- Brain Science Institute at Johns Hopkins
- National Alliance for Research on Schizophrenia and Depression
- Mathers Foundation
- Lookout Fund
- J.S.McDonnell Foundation
- Helen Hay Whitney Foundation
- Foundation for Advanced Research in the Medical Sciences
- Dr. Richard and Mavis Fowler
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Epigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces between genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from adult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural niche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can lead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the mammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.
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