Journal
NATURE NEUROSCIENCE
Volume 13, Issue 9, Pages 1053-1055Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2613
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Funding
- US National Institutes of Health [MH63394]
- Ramon Areces Foundation
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AKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term depression solely because of its interaction with calcineurin.
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