Journal
NATURE NEUROSCIENCE
Volume 13, Issue 11, Pages 1351-1353Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2642
Keywords
-
Categories
Funding
- Pratt Foundation
- Israel Science Foundation
- Nella and Leon Benoziyo Center for Neurosciences
- Nella and Leon Benoziyo Center for Neurological Diseases
- Carl and Micaela Einhorn-Dominic Brain Research Institute
- Irwin Green Alzheimer's Research Fund
- Gerhard and Hannah Bacharach
Ask authors/readers for more resources
DNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and that chronic social stress in adult mice induced long-term demethylation of this genomic region. Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available