Journal
NATURE NEUROSCIENCE
Volume 13, Issue 5, Pages 541-U43Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2536
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Funding
- US National Institutes of Health [R01NS045702, R01NS056427, K99NS057944, R01NS047344, R01AG024984, R01NS048271]
- Hungarian National Office for Research and Technology [GVOP-3.1.1.-2004-05-0230-/3.0]
- US National Institutes of Health Intellectual and Developmental Disabilities Research Center [P30HD40677]
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The mechanisms that regulate the developmental potential of adult neural progenitor populations under physiological and pathological conditions remain poorly defined. Glutamic acid decarboxylase 65 (GAD65)- and Doublecortin (Dcx)-expressing cells constitute major progenitor populations in the adult mouse subventricular zone (SVZ). Under normal physiological conditions, SVZ-derived GAD65-positive and Dcx-positive cells expressed the transcription factor Pax6 and migrated along the rostral migratory stream to the olfactory bulb to generate interneurons. After lysolecithin-induced demyelination of corpus callosum, however, these cells altered their molecular and cellular properties and migratory path. Demyelination upregulated chordin in the SVZ, which redirected GAD65-positive and Dcx-positive progenitors from neuronal to glial fates, generating new oligodendrocytes in the corpus callosum. Our findings suggest that the lineage plasticity of SVZ progenitor cells could be a potential therapeutic strategy for diseased or injured brain.
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