Journal
NATURE NEUROSCIENCE
Volume 13, Issue 3, Pages 281-283Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2494
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Funding
- AVENIR/INSERMFondation Bettencourt-Schueller
- Agence National de la Recherche [ANR-06-NEURO-043-01]
- European Foundation
- European Union [HEALTH-F2-2008-223713]
- European Commission Network of European Neuroscience Institutes (ENINET) [LSHM-CT-2005-19063]
- Basque Country Government [GIC07/70-IT-432-07]
- Red de Trastornos Adictivos
- Instituto de Salud Carlos III
- Ministerio de Ciencia e Innovacion
- Gobierno de Espana [RD07/0001/2001]
- Basque Country University
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Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB1 receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.
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