Journal
NATURE NEUROSCIENCE
Volume 13, Issue 6, Pages 664-666Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2560
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Funding
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging
- National Institute on Drug Abuse
- American Health Assistance Foundation
- Evelyn F. McKnight Brain Research Foundation
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A behavioral memory's lifetime represents multiple molecular lifetimes, suggesting the necessity for a self-perpetuating signal. One candidate is DNA methylation, a transcriptional repression mechanism that maintains cellular memory throughout development. We found that persistent, gene-specific cortical hypermethylation was induced in rats by a single, hippocampus-dependent associative learning experience and pharmacologic inhibition of methylation 1 month after learning disrupted remote memory. We propose that the adult brain utilizes DNA methylation to preserve long-lasting memories.
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