Journal
NATURE NEUROSCIENCE
Volume 13, Issue 12, Pages 1454-1456Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2690
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Funding
- European Research Council
- Interdisciplinary Center of Clinical Research at the University Hospital of the University of Erlangen-Nuremberg
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Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin) in neuromuscular preparations from Drosophila, frog and mouse, as well as rat cultured neurons, we found that the same vesicles participate in active and spontaneous release.
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