Journal
NATURE NEUROSCIENCE
Volume 13, Issue 12, Pages 1451-1453Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2695
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Funding
- Deutsche Forschungsgemeinschaft [Kl 1334/1-1]
- Max Planck foundation
- International Max Planck Research School in Neurosciences Gottingen
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There is a longstanding controversy on the identity of synaptic vesicles undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested that spontaneous release is driven by a resting pool of synaptic vesicles refractory to stimulation. We found that cross-depletion of spontaneously or actively recycling synaptic vesicle pools occurred on stimulation in rat hippocampal neurons and identified the recycling pool as a major source of spontaneous release.
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