Journal
NATURE NEUROSCIENCE
Volume 13, Issue 3, Pages 333-U14Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2493
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Funding
- Canadian Institutes of Health Research
- Achievers in Medical Sciences and T. Chen Fong Award
- Alberta Heritage Foundation for Medical Research (AHFMR)
- National Sciences and Engineering Research Council
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Kv4 low voltage-activated A-type potassium channels are widely expressed in excitable cells, where they control action potential firing, dendritic activity and synaptic integration. Kv4 channels exist as a complex that includes K+ channel-interacting proteins (KChIPs), which contain calcium-binding domains and therefore have the potential to confer calcium dependence on the Kv4 channel. We found that T-type calcium channels and Kv4 channels form a signaling complex in rat that efficiently couples calcium influx to KChIP3 to modulate Kv4 function. This interaction was critical for allowing Kv4 channels to function in the subthreshold membrane potential range to regulate neuronal firing properties. The widespread expression of these channels and accessory proteins indicates that the Cav3-Kv4 signaling complex is important for the function of a wide range of electrically excitable cells.
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