Journal
NATURE NEUROSCIENCE
Volume 12, Issue 9, Pages 1090-1092Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2385
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Funding
- Epilepsy Foundation
- US National Institutes of Health training
- Texas Advanced Research Program [3594-0029-2007, 10019-0013-2006]
- Ellison Medical Foundation [AG-NS-0371-06]
- Welch Foundation [I-1660]
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The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.
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