Journal
NATURE NEUROSCIENCE
Volume 12, Issue 11, Pages 1361-1363Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2432
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Funding
- National Institutes of Neurological Disorders and Stroke [R01 NS046006]
- US National Institutes of Health [AG017617, NS045205]
- [BMBF-01GI0705]
- [SFB-TR43, Exc 25]
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In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
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