Journal
NATURE NEUROSCIENCE
Volume 13, Issue 1, Pages 22-24Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2459
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Funding
- Research Grants Council of Hong Kong [HKUST6429/06M, N_HKUST605/07, HKUST6/CRF/08, 663107, AoE/B-15/01]
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In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons.
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