Journal
NATURE NEUROSCIENCE
Volume 12, Issue 7, Pages 826-828Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2349
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Funding
- Michael J. Fox Foundation
- US National Institutes of Health
- Department of Defense
- Parkinson's Disease Foundation
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Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.
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