Journal
NATURE NEUROSCIENCE
Volume 12, Issue 9, Pages 1087-1089Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2382
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Funding
- James S. McDonnell Foundation [220020180]
- US National Institutes of Health [CA114197, CA107193]
- NATIONAL CANCER INSTITUTE [R01CA114197, R01CA107193] Funding Source: NIH RePORTER
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Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.
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