Journal
NATURE NEUROSCIENCE
Volume 12, Issue 4, Pages 387-389Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2290
Keywords
-
Categories
Funding
- US National Institutes of Health [P30 NS057105, NS040745, AG13730, DA 020812]
- Washington University Alzheimer's Disease Research Center National Institute on Aging [NIA P50 AG05681-25]
- Hope Center for Neurological Disorders
- Keck Foundation
Ask authors/readers for more resources
Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available