Journal
NATURE NEUROSCIENCE
Volume 12, Issue 2, Pages 113-115Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2244
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Funding
- National Institute of Neurological Disorders and Stroke [NS30687, NS52819]
- National 973 Basic Research Program of China [2006CB503803, 2009CB941403]
- National Institute of Child Health and Human Development
- National Institute of Mental Health
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Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.
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