Journal
NATURE NEUROSCIENCE
Volume 12, Issue 2, Pages 116-118Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2255
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Funding
- US National Eye Institute [EY016052]
- Esther and Joseph Klingenstein Foundation
- University of California Los Angeles Center for Autism Research and Treatment
- US National Institute for Mental Health
- National Institute of Child Health and Human Development
- National Institute on Deafness and Other Communication Disorders
- National Institute of Neurological Disorders and Stroke [MH68172]
- Ruth L. Kirchstein National Research Service [GM07185]
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Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.
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