Journal
NATURE NEUROSCIENCE
Volume 12, Issue 8, Pages 970-972Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2356
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Funding
- NCRR NIH HHS [UL1-RR025005, UL1 RR025005] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007057] Funding Source: Medline
- NIMH NIH HHS [R01 MH078160, R01 MH085328] Funding Source: Medline
- NINDS NIH HHS [R01 NS048527-02, K02 NS044850, R01 NS048527-06A1, R01 NS048527-01A2, K02 NS044850-01A2, R01 NS048527-05, K02 NS044850-02, R01 NS048527-04, K02 NS044850-03, R01 NS037422, K02 NS044850-04, R01 NS048527, R01 NS048527-03, R01 NS037422-11, K02 NS044850-05] Funding Source: Medline
- Autism Speaks [AS1739, AS2506, AS2384] Funding Source: Medline
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Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.
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