Journal
NATURE NEUROSCIENCE
Volume 12, Issue 1, Pages 21-23Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2230
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Funding
- US National Institutes of Health [MH71401, NS056529]
- Medical Research Council [MC_U138197107] Funding Source: researchfish
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH071401] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [F31NS056529] Funding Source: NIH RePORTER
- MRC [MC_U138197107] Funding Source: UKRI
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Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABA(A) receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.
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