Journal
NATURE NEUROSCIENCE
Volume 11, Issue 7, Pages 752-753Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2139
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIDDK NIH HHS [R01 DK071320, RL1DK081185, PL1 DK081182-01, PL1 DK081182, P01 DK056116, RL1 DK081185-01, RL1 DK081185, R01DK71320, K08 DK068069, K08DK068069-01A2, P01DK56116] Funding Source: Medline
- NIMH NIH HHS [P50 MH066172, P50MH66172] Funding Source: Medline
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We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
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