Journal
NATURE NEUROSCIENCE
Volume 11, Issue 6, Pages 631-633Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2120
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Funding
- NIMH NIH HHS [R01 MH075957-01A2, R01 MH075957] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH075957] Funding Source: NIH RePORTER
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The introduction of two microbial opsin- based tools, channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to neuroscience has generated interest in fast, multimodal, cell type-specific neural circuit control. Here we describe a cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted similar to 70 nm compared with ChR2. These results demonstrate fast photostimulation with yellow light, thereby defining a functionally distinct third category of microbial rhodopsin proteins.
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