Journal
NATURE NEUROSCIENCE
Volume 11, Issue 9, Pages 998-1000Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2167
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Funding
- US National Institutes of Health [RO1 DK071051, PO1 DK56116, RO1 DK071320, RO1 DK53301]
- Beth Israel Deaconess Medical Center Transgenic Facility
- Boston Obesity Nutrition Research Center [P30 DK046200]
- Boston Area Diabetes Endocrinology Research Center [P30 DK057521]
- US National Institutes of Health-funded Boston Obesity Nutrition Research Center [P30 DK046200]
- North American Association for the Study of Obesity
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK056116, R01DK053301, R01DK071051, R01DK056690, P30DK057521, R01DK071320, P30DK046200] Funding Source: NIH RePORTER
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The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.
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