Journal
NATURE NEUROSCIENCE
Volume 11, Issue 7, Pages 744-745Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2125
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Funding
- Medical Research Council [G0400571] Funding Source: Medline
- Alzheimers Research UK [ART-EG2004B-2] Funding Source: researchfish
- Medical Research Council [G0400571] Funding Source: researchfish
- MRC [G0400571] Funding Source: UKRI
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NMDA receptors are necessary for both synaptic potentiation and depression, but the precise location of these receptors has not been established. By loading MK-801 into pre- or postsynaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not presynaptic, NMDA receptors, whereas synaptic depression requires presynaptic, but not postsynaptic, NMDA receptors.
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