Journal
NATURE NEUROSCIENCE
Volume 11, Issue 7, Pages 746-748Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2129
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Funding
- MRC [G0301057] Funding Source: UKRI
- Medical Research Council [G0301057, G0801693] Funding Source: Medline
- Medical Research Council [G0301057] Funding Source: researchfish
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Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and Tecta(Delta ENT/Delta ENT) mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from Tecta(Delta ENT/Delta ENT) mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.
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