Journal
NATURE NANOTECHNOLOGY
Volume 9, Issue 1, Pages 44-47Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2013.230
Keywords
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Funding
- Engineering and Physical Sciences Research Council [EP/G037930/1]
- Biotechnology and Biological Sciences Research Council [BB/G019118/1]
- Royal Society-Wolfson Research Merit Award
- Engineering and Physical Sciences Research Council [GR/A10274/01] Funding Source: researchfish
- BBSRC [BB/G019118/1] Funding Source: UKRI
- EPSRC [EP/G037930/1] Funding Source: UKRI
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In eukaryotic cells, cargo is transported on self-organized networks of microtubule trackways by kinesin and dynein motor proteins(1,2). Synthetic microtubule networks have previously been assembled in vitro(3-5), and microtubules have been used as shuttles to carry cargoes on lithographically defined tracks consisting of surface-bound kinesin motors(6,7). Here, we show that molecular signals can be used to program both the architecture and the operation of a self-organized transport system that is based on kinesin and microtubules and spans three orders of magnitude in length scale. A single motor protein, dimeric kinesin-1(8), is conjugated to various DNA nanostructures to accomplish different tasks. Instructions encoded into the DNA sequences are used to direct the assembly of a polar array of microtubules and can be used to control the loading, active concentration and unloading of cargo on this track network, or to trigger the disassembly of the network.
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