Journal
NATURE NANOTECHNOLOGY
Volume 6, Issue 7, Pages 452-460Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2011.79
Keywords
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Funding
- KRICT [KK-0904-02, SI-1110]
- Nano RD Program [2009-0082861]
- NRF [2009-0081511]
- MEST [2010-0020-795]
- KME
- 21C Frontier Functional Proteomics Project [FPR08-A2-150]
- Ministry of Education, Science and Technology [2008-02890]
- Ministry of Knowledge Economy [10033183, 10037397]
- Korea Research Institute of Chemical Technology
- Pharmaceutical Research Institute
- Agriculture & Forestry Technology Management Center, Republic of Korea [2008-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Korea Evaluation Institute of Industrial Technology (KEIT) [10033467] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Council of Science & Technology (NST), Republic of Korea [SI-1110] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2011-0018198, 2007-2002943, 2008-02890, 2011-0002131, 13-2008-00-015-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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An ideal surface-enhanced Raman scattering (SERS) nanostructure for sensing and imaging applications should induce a high signal enhancement, generate a reproducible and uniform response, and should be easy to synthesize. Many SERSactive nanostructures have been investigated, but they suffer from poor reproducibility of the SERS-active sites, and the wide distribution of their enhancement factor values results in an unquantifiable SERS signal. Here, we show that DNA on gold nanoparticles facilitates the formation of well-defined gold nanobridged nanogap particles (Au-NNP) that generate a highly stable and reproducible SERS signal. The uniform and hollow gap (similar to 1 nm) between the gold core and gold shell can be precisely loaded with a quantifiable amount of Raman dyes. SERS signals generated by Au-NNPs showed a linear dependence on probe concentration (R(2) > 0.98) and were sensitive down to 10 fM concentrations. Single-particle nano-Raman mapping analysis revealed that >90% of Au-NNPs had enhancement factors greater than 1.0 x 10(8), which is sufficient for single-molecule detection, and the values were narrowly distributed between 1.0 x 10(8) and 5.0 x 10(9).
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