Journal
NATURE NANOTECHNOLOGY
Volume 6, Issue 10, Pages 615-624Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2011.129
Keywords
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Funding
- Midwestern Cancer Nanotechnology Training Center [NIH-NCI R25 CA154015]
- National Institutes of Health [R21 CA155863]
- National Science Foundation [EEC-0425626]
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Nanopore analysis is an emerging technique that involves using a voltage to drive molecules through a nanoscale pore in a membrane between two electrolytes, and monitoring how the ionic current through the nanopore changes as single molecules pass through it. This approach allows charged polymers (including single-stranded DNA, double-stranded DNA and RNA) to be analysed with subnanometre resolution and without the need for labels or amplification. Recent advances suggest that nanopore-based sensors could be competitive with other third-generation DNA sequencing technologies, and may be able to rapidly and reliably sequence the human genome for under $1,000. In this article we review the use of nanopore technology in DNA sequencing, genetics and medical diagnostics.
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