Journal
NATURE NANOTECHNOLOGY
Volume 5, Issue 8, Pages 607-611Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2010.126
Keywords
-
Funding
- U.S. National Institutes of Health
- Institute of Paper Science and Technology
Ask authors/readers for more resources
A major barrier to drug and gene delivery is crossing the cell's plasma membrane. Physical forces applied to cells via electroporation(1), ultrasound(2) and laser irradiation(3-6) generate nanoscale holes in the plasma membrane for direct delivery of drugs into the cytoplasm. Inspired by previous work showing that laser excitation of carbon nanoparticles can drive the carbon-steam reaction to generate highly controlled shock waves(7-10), we show that carbon black nanoparticles activated by femtosecond laser pulses can facilitate the delivery of small molecules, proteins and DNA into two types of cells. Our initial results suggest that interaction between the laser energy and carbon black nanoparticles may generate photo-acoustic forces by chemical reaction to create transient holes in the membrane for intracellular delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available