Journal
NATURE METHODS
Volume 15, Issue 10, Pages 785-+Publisher
NATURE RESEARCH
DOI: 10.1038/s41592-018-0121-0
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Funding
- Cancer Research UK [C13474/A18583, C6946/A14492, A17197]
- Wellcome Trust [104640/Z/14/Z, 092096/Z/10/Z, 207507, 207498/Z/17/Z]
- Human Frontier Science Program (HFSP) [LT000558/2015]
- European Molecular Biology Organization (EMBO) [ALTF1622-2014]
- Blavatnik Family Foundation
- UK Medical Research Council
- EMBL
- NIGMS [R01GM104475, R01GM115649]
- City University of Hong Kong [9610363, 7200520]
- Croucher Foundation [9500030]
- Hong Kong RGC [9048103, 9054020]
- NSFC (Excellent Young Scientist Fund) [81522025]
- Academy of Medical Sciences, UK (Newton Advanced Fellowship)
- MRC [MC_UU_00007/12] Funding Source: UKRI
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The structural flexibility of RNA underlies fundamental biological processes, but there are no methods for exploring the multiple conformations adopted by RNAs in vivo. We developed cross-linking of matched RNAs and deep sequencing (COMRADES) for in-depth RNA conformation capture, and a pipeline for the retrieval of RNA structural ensembles. Using COMRADES, we determined the architecture of the Zika virus RNA genome inside cells, and identified multiple site-specific interactions with human noncoding RNAs.
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