Journal
NATURE METHODS
Volume 11, Issue 6, Pages 629-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2935
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Funding
- Louise and Alan Edwards Foundation
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- US National Science Foundation
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We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing.
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