Journal
NATURE METHODS
Volume 11, Issue 8, Pages 821-824Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3031
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Funding
- Alex's Lemonade Stand Foundation
- Leukemia & Lymphoma Society
- American Cancer Society
- Massachusetts General Hospital Howard Goodman Fellowship
- US National Institutes of Health [F32DK098875, R240D016761, 1R01CA154923]
- China Scholarship Council
- Cancer Care Nova Scotia Peggy Davison Clinician
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Cell transplantation into adult zebrafish has lagged behind mouse models owing to the lack of immunocompromised strains. Here we have created rag2(E45fs) mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund. Mutant fish engraft muscle, blood stem cells and various cancers. rag2(E45fs) mutant zebrafish are the first immunocompromised zebrafish model that permits robust, long-term engraftment of multiple tissues and cancer.
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