Journal
NATURE METHODS
Volume 11, Issue 10, Pages 1045-1048Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3101
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Funding
- European Research Council [ERC-2013-StG-337965]
- Swiss National Science Foundation [PP00P3_133670]
- EU Seventh Framework Program Reintegration grant [FP7-PEOPLE-2010-RG-277147]
- Promedica Stiftung [2-70669-11]
- Natural Sciences and Engineering Research Council of Canada [PGSD3-403808-2011]
- Operational Program, Research and Development for Innovations [CZ.1.05/2.1.00/03.0124]
- short-term EMBO fellowship [ASTF 475-20130]
- SystemX.ch initiative
- Swiss National Science Foundation (SNF) [PP00P3_133670] Funding Source: Swiss National Science Foundation (SNF)
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We describe a proteomic screening approach based on the concept of sentinel proteins, biological markers whose change in abundance characterizes the activation state of a given cellular process. Our sentinel assay simultaneously probed 188 biological processes in Saccharomyces cerevisiae exposed to a set of environmental perturbations. The approach can be applied to analyze responses to large sets of uncharacterized perturbations in-high throughput.
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