Journal
NATURE METHODS
Volume 11, Issue 6, Pages 649-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2931
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Funding
- European Research Council (ERC) under the European Union/ERC [261151]
- MRC (UK) Centenary award
- MRC (UK) [MC_U105192715]
- MRC [MC_U105192715] Funding Source: UKRI
- Medical Research Council [MC_U105192715] Funding Source: researchfish
- European Research Council (ERC) [261151] Funding Source: European Research Council (ERC)
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Despite its many favorable properties as a sample support for biological electron microscopy, graphene is not widely used because its hydrophobicity precludes reliable protein deposition. We describe a method to modify graphene with a low-energy hydrogen plasma, which reduces hydrophobicity without degrading the graphene lattice. Use of plasma-treated graphene enables better control of protein distribution in ice for electron cryo-microscopy and improves image quality by reducing radiation-induced sample motion.
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