Journal
NATURE METHODS
Volume 11, Issue 4, Pages 410-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2878
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Funding
- Columbia University, a US National Institutes of Health Director's New Innovator Award
- US Army Research Office [W911NF-12-1-0594]
- Alfred P.Sloan Research Fellowship
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Sensitive and specific visualization of small biomolecules in living systems is highly challenging. We report stimulated Raman-scattering imaging of alkyne tags as a general strategy for studying a broad spectrum of small biomolecules in live cells and animals. We demonstrate this technique by tracking alkyne-bearing drugs in mouse tissues and visualizing de novo synthesis of DNA, RNA, proteins, phospholipids and triglycerides through metabolic incorporation of alkyne-tagged small precursors.
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