Journal
NATURE METHODS
Volume 12, Issue 1, Pages 85-91Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3204
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Funding
- US National Institutes of Health [P41 GM103426, A.J.0.
- P50GM103368 t]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P41GM103426, P50GM103368] Funding Source: NIH RePORTER
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cellPACK assembles computational models of the biological mesoscale, an intermediate scale (10-100 nm) between molecular and cellular biology scales. celIPACK's modular architecture unites existing and novel packing algorithms to generate, visualize and analyze comprehensive threedimensional models of complex biological environments that integrate data from multiple experimental systems biology and structural biology sources. cellPACK is available as open-source code, with tools for validation of models and with 'recipes' and models for five biological systems: blood plasma, cytoplasm, synaptic vesicles, HIV and a mycoplasma cell. We have applied cellPACK to model distributions of HIV envelope protein to test several hypotheses for consistency with experimental observations. Biologists, educators and outreach specialists can interact with cellPACK models, develop new recipes and perform packing experiments through scripting and graphical user interfaces at http://cellPACK.org/.
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