Journal
NATURE METHODS
Volume 11, Issue 11, Pages 1131-1134Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3139
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Funding
- Wellcome Trust [089312/Z/09/Z]
- EPSRC [EP/I01974X/1]
- BBSRC [BB/H001905/1]
- Wellcome Trust [089312/Z/09/Z] Funding Source: Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/H001905/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I01974X/1] Funding Source: researchfish
- BBSRC [BB/H001905/1] Funding Source: UKRI
- EPSRC [EP/I01974X/1] Funding Source: UKRI
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We describe a method for performing time-resolved X-ray crystallographic experiments based on the Hadamard transform, in which time resolution is defined by the underlying periodicity of the probe pulse sequence, and signal/noise is greatly improved over that for the fastest pump-probe experiments depending on a single pulse. This approach should be applicable on standard synchrotron beamlines and will enable high-resolution measurements of protein and small-molecule structural dynamics. It is also applicable to other time-resolved measurements where a probe can be encoded, such as pump-probe spectroscopy.
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