Journal
NATURE METHODS
Volume 11, Issue 10, Pages 1041-1044Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3072
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC)/Pfizer CASE Studentship [BB/I532329/1]
- Cancer Research UK Career Establishment Award [C37293/A12905]
- BBSRC [BB/J017450/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J017450/1] Funding Source: researchfish
- Cancer Research UK [12905] Funding Source: researchfish
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In targeted proteomics it is critical that peptides are not only proteotypic but also accurately represent the level of the protein (quantotypic). Numerous approaches are used to identify proteotypic peptides, but quantotypic properties are rarely assessed. We show that measuring ratios of proteotypic peptides across biological samples can be used to empirically identify peptides with good quantotypic properties. We applied this technique to identify quantotypic peptides for 21% of the human kinome.
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