Journal
NATURE METHODS
Volume 12, Issue 2, Pages 134-U168Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.3210
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Funding
- China Scholarship Council (CSC) [[2008]3027]
- Carnegie Mellon University Dowd-ICES Fellowship
- NIH Biomechanics in Regenerative Medicine T32 training grant [T32EB003392]
- Bertucci Graduate Fellowship
- NIH Director's New Innovator Award [DP2HL117750]
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Our Patterning on Topography (PoT) printing technique enables fibronectin, laminin and other proteins to be applied to biomaterial surfaces in complex geometries that are inaccessible using traditional soft lithography techniques. Engineering combinatorial surfaces that integrate topographical and biochemical micropatterns enhances control of the biotic-abiotic interface. Here, we used this method to understand cardiomyocyte response to competing physical and chemical cues in the microenvironment.
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