Journal
NATURE METHODS
Volume 10, Issue 8, Pages 751-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/nmeth.2521
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Funding
- US National Institutes of Health [GM073913, CA164468, EB013571]
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Near-infrared fluorescent proteins (FPs) are in high demand for in vivo imaging. We developed four spectrally distinct near-infrared FPs-iRFP670, iRFP682, iRFP702 and iRFP720-from bacterial phytochromes. iRFPs exhibit high brightness in mammalian cells and tissues and are suitable for long-term studies. iRFP670 and iRFP720 enable two-color imaging with standard approaches in living cells and mice. The four new iRFPs and the previously engineered iRFP713 allow multicolor imaging with spectral unmixing in living mice.
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