4.8 Article

METHOD OF THE YEAR Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry

Journal

NATURE METHODS
Volume 10, Issue 1, Pages 28-34

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.2309

Keywords

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Funding

  1. Broad Institute of MIT and Harvard
  2. US National Cancer Institute part of the Clinical Proteomics Tumor Analysis Consortium initiative [U24CA160034]
  3. National Heart, Lung, and Blood Institute [HHSN268201000033C, R01HL096738]
  4. Entertainment Industry Foundation
  5. Komen Foundation
  6. NATIONAL CANCER INSTITUTE [U24CA160034] Funding Source: NIH RePORTER
  7. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL096738] Funding Source: NIH RePORTER

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Targeted mass spectrometry (MS) is becoming widely used in academia and in pharmaceutical and biotechnology industries for sensitive and quantitative detection of proteins, peptides and post-translational modifications. Here we describe the increasing importance of targeted MS technologies in clinical proteomics and the potential key roles these techniques will have in bridging biomedical discovery and clinical implementation.

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