Journal
NATURE METHODS
Volume 10, Issue 3, Pages 243-245Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2366
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Funding
- US National Institutes of Health (NIH) [DP1 OD006862, NIH P50 HG005550, R01 NS073124]
- Jim and Ann Orr Massachusetts General Hospital Research Scholar Award
- US National Science Foundation Graduate Research Fellowship
- NIH [T32 CA009216, P30 NS45776]
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Artificial activators designed using transcription activator like effector (TALE) technology have broad utility, but previous studies suggest that these monomeric proteins often exhibit low activities. Here we demonstrate that TALE activators can robustly function individually or in synergistic combinations to increase expression of endogenous human genes over wide dynamic ranges. These findings will encourage applications of TALE activators for research and therapy, and guide design of monomeric TALE-based fusion proteins.
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