Journal
NATURE METHODS
Volume 10, Issue 10, Pages 989-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2610
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We report that low percentages of dimethylsulfoxide (DMSO) in liquid chromatography solvents lead to a strong enhancement of electrospray ionization of peptides, improving the sensitivity of protein identification in bottom-up proteomics by up to tenfold. The method can be easily implemented on any LC-MS/MS system without modification to hardware or software and at no additional cost.
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