Journal
NATURE METHODS
Volume 10, Issue 10, Pages 957-963Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2649
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Funding
- US National Institutes of Health NHGRI grant [P50 HG005550]
- Department of Energy [DE-FG02-02ER63445]
- Wyss Institute for Biologically Inspired Engineering
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RNA-guided Cas9 nucleases derived from clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the genomes of diverse organisms. We believe tools and techniques based on Cas9, a single unifying factor capable of colocalizing RNA, DNA and protein, will grant unprecedented control over cellular organization, regulation and behavior. Here we describe the Cas9 targeting methodology, detail current and prospective engineering advances and suggest potential applications ranging from basic science to the clinic.
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