Journal
NATURE METHODS
Volume 10, Issue 11, Pages 1105-1107Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2647
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Funding
- US National Institutes of Health (NIH)
- Baltimore Polycystic Kidney Disease Research and Clinical Core Center [GM092930, DK065655, DK090868]
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Society for the Promotion of Science
- Agency for Science, Technology and Research in Singapore
- Grants-in-Aid for Scientific Research [23370083, 23229001, 24657081, 24770183] Funding Source: KAKEN
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Visualization of signal transduction in live primary cilia constitutes a technical challenge owing to the organelle's submicrometer dimensions and close proximity to the cell body. Using a genetically encoded calcium indicator targeted to primary cilia, we visualized calcium signaling in cilia of mouse fibroblasts and kidney cells upon chemical or mechanical stimulation with high specificity, high sensitivity and wide dynamic range.
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