Journal
NATURE METHODS
Volume 10, Issue 10, Pages 985-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/nmeth.2611
Keywords
-
Categories
Funding
- Wellcome Trust [WT098051]
Ask authors/readers for more resources
We present DeNovoGear software for analyzing de novo mutations from familial and somatic tissue sequencing data. DeNovoGear uses likelihood-based error modeling to reduce the false positive rate of mutation discovery in exome analysis and fragment information to identify the parental origin of germ-line mutations. We used DeNovoGear on human whole-genome sequencing data to produce a set of predicted de novo insertion and/or deletion (indel) mutations with a 95% validation rate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available