Journal
NATURE METHODS
Volume 10, Issue 12, Pages 1192-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.2724
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Funding
- US National Institutes of Health [5DP1LM01150-05]
- Allen Distinguished Investigator Award
- US National Science Foundation
- Stanford University
- European Molecular Biology Organization [ALTF1371-2011]
- Weiland Engineering Fellowship
- Rensselaer Engineering Fellowship
- Siebel Scholars Fellowship
- US National Defense Science and Engineering Graduate Fellowship
- Stanford Graduate Fellowship
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To test the promise of whole-cell modeling to facilitate scientific inquiry, we compared growth rates simulated in a whole-cell model with experimental measurements for all viable single-gene disruption Mycoplasma genitalium strains. Discrepancies between simulations and experiments led to predictions about kinetic parameters of specific enzymes that we subsequently validated. These findings represent, to our knowledge, the first application of whole-cell modeling to accelerate biological discovery.
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