Journal
NATURE METHODS
Volume 9, Issue 9, Pages 910-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.2133
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Funding
- US National Cancer Institute contracts Physical Sciences Oncology Center [U54CA143874, R21 CA137695]
- National Institutes of General Medical Sciences (NIGMS) [EUREKA R01GM085457]
- NIGMS
- Kwanjeong Educational Foundation, South Korea
- National Science Foundation Graduate Research Fellowship
- Marie Curie International Reintegration Grant [PIRG-GA-2010-277062]
- Israeli Centers of Research Excellence (I-CORE) program [41/11]
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We introduce a microfluidic system for simultaneously measuring single-cell mass and cell cycle progression over multiple generations. We use this system to obtain over 1,000 h of growth data from mouse lymphoblast and pro-B-cell lymphoid cell lines. Cell lineage analysis revealed a decrease in the growth rate variability at the G1-S phase transition, which suggests the presence of a growth rate threshold for maintaining size homeostasis.
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